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But for

Brad* created a personal webpage sometime back in 1996. That spurred my brother and me to create our own website on AOL — The Owings Brothers Page (archived). This site had grown stagnant some two years later so I created the first embodiment of The Justin Owings Page (archived), which chronicled 4th period lunch, published bad pictures of friends, made fun of teachers, and archived ostensibly humorous IM conversations. A few short years later, a senior in college, I was tasked to create a website for an IT class. I went a little over the top for the assignment and created a new and improved (?) Justin Owings Page (archived). Highlights of this endeavor mostly revolve around Mr. Mister, the yam — not the band.

One of the last and likely most enjoyable, educational classes I took in college was Law and Economics by Professor David Mustard. The only “textbook” for this class was David D. Friedman’s Law’s Order, a fascinating read about how law has been evolved through economics.

In fall 2004, springing from discussions on the subject with Shannon mixed with the prodding of my older brother, I created Contraddiction. Contraddiction was doomed from the start as I had no steady internet access, relying on the sporadically available, unencrypted wifi clouds emanating from neighboring apartments. Regardless, I enjoyed blogging and it left me wanting more.

In mid-2005 we secured steady internet access. In January 2006 I began reexamining (at a high level) going back to school, specifically to secure a Ph.D. in either Accountancy or Economics. I emailed Professor Mustard who graciously responded — but I quickly determined that a Ph.D. was not for me. Yet I was reminded of how much I enjoyed that college class on economics and law. Some googling resulted in the discovery that David Friedman had started a blog, Ideas. I became a regular reader.

DDF wrote a post on Gangs and I was spurred to to comment. Another commenter on the same post was a fellow named Aaron who, as I realized upon randomly following the link associated with his name, also lived in Atlanta, working at Emory. From Aaron’s homepage, I also found Aaron’s Furl, which I subscribed to via RSS in Gmail.

The insights and discussion at Friedman’s blog inspired me to take another stab at a website, one replete with a full-fledged blog. Around my 25th birthday (February), I created autoDogmatic.

I invited three friends to co-blog on aD, but mostly, I was the only one blogging regularly. Six months in and all the while reading Aaron’s Furl, I stumbled upon an article written by Aaron about the Federal Reserve’s reserve requirements. An interesting read (if you’re into that kinda thing), there was one link in the article that was broken. I searched around for the correct link and emailed it to Aaron, mentioning to him that I had been subscribing to his Furl for the past few months. We got to pinging emails back and forth and realized we had a good bit in common.

We decided to meet up for a beer and a discussion. We were both probably shocked at having met another anarcho-capitalist within Atlanta. And as Aaron wasn’t blogging anywhere at the time, I invited him to join forces on autoDogmatic. He accepted.

Aaron blogged mostly on economics and I stuck mostly to politics, but our overarching theme intersected significantly — we were both staunchly anti-government, anti-Federal Reserve and, most importantly, pro-freedom.

A few months passed and around the end of December 2006, Aaron emailed me a link to a pretty basic webpage he had created titled, “The Mortgage Lender Implode-O-Meter“, which he was going to use to track as mortgage lenders went bust (Old news these days, I know!). I created a logo for it and helped him out a bit on design. Within weeks, MLI had out-trafficked autoDogmatic. By March it was being featured on CNBC.

The Implode-O-Meter’s success meant that it required a lot of Aaron’s attention, and he was still working full-time at his “day job”. I was helping out when I could. Aaron knew I was tired of my day-job and asked me to join forces and take MLI to the next level. With a bit of prodding from Aaron and a nervous, but supportive spouse, I took up the offer in May 2007. This ultimately led to the formation of our own company, Implode-Explode Heavy Industries, in July, which owns all the Implode-O-Meters as well as a few other sites.

I rediscovered all sorts of new freedoms having left corporate America. Most notably, I suddenly felt free to blog using my real name. Within a few months, I picked up justinowings.com and established this site.

That just about brings things to the present.

Just a couple days back, my friend David, who just himself left the traditional j-o-b, started his own blog. And it was his first post that got me thinking on how I got here to the blogosphere owning my own web-media business utterly clueless as to what will come next.

But for the aforementioned events — many of which were small things, entirely unworthy of note — I would not be here writing this post.

De Vany’s stochasticity of life is in this pseudo-randomness. Life is fluid, complex, and frequently molded in big ways by things unnoticed at first, and poorly understood later, if ever.

The only lesson I can glean from it all is to follow my whims, no matter how fanciful or silly they are because those whims apparently add up.

Life is fantastic that way.

*To bring it full circle, it seems that some twelve years later, Brad is blogging these days, too.

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George Carlin, R.I.P.

George Carlin died at age 71. He was a damn hilarious comedian, philosopher and human observer. That is redundant.

Here are a couple of interviews with Carlin:

The A.V. Club circa 1999:

GC: Well, they say, “If you scratch a cynic, underneath you’ll find a disappointed idealist.” So I would imagine there’s some little flame, however weak, that still burns, but I know time is against my seeing that. I think this world would need a long time, maybe a thousand years, to evolve to what may be a golden age, and in the meantime, there are all these very small, parochial struggles between peoples of different language and color and arbitrary political and national boundaries. And my understanding of it is that there is no hope, because I think we’re locked in by commerce. The whole idea of the pursuit of goods and possessions has completely corrupted the human experience, along with religion, which I think limits the intellect. So with those two things in place as firmly as they are, I don’t see any hope for getting around them short of some sort of interesting cataclysm. So I root for a cataclysm, for its own sake, just as entertainment. I don’t even care if it has a good result. We’re circling the drain, and I just like seeing the circles get faster and shorter all the time.

Mother Jones circa 1997 (Carlin was actually married for at least 30 years prior to his wife’s death):

Q: Are you lonely?

A: There is a core of loneliness. It’s partly existential. Secondly, I was raised a loner. My parents were not there. My father was asked to leave because he couldn’t metabolize ethanol. Actually, my mother ran away with us when I was 2 months old and my brother was 5. Real dramatic stuff: down the fire escape, through backyards.

So, I sort of raised myself. I was alone a lot and I invented myself — I lived through the radio and through my imagination.

One of the interesting things about “outsidership” is that underneath it there’s a longing to belong. I just wish the thing I refused to belong to — the species, Western capital culture — was a little more respectable.

The full interviews are worth reading if you have the time.

I need to memorize Carlin’s pitch on why he doesn’t vote because its hard to imagine saying it any better than he does here:

And his incredibly irreverent critique of religion:

In both of the above videos, Carlin lays bare some stark truths and he does it with succinct, seamless execution. You hear the audience die of laughter on hearing them. The laughter springs from the incongruence of the truth Carlin speaks and the beliefs the audience holds dear. What’s sad is that the humor masks the enlightenment, allowing the audience to go home, with misguided beliefs still intact. Nonetheless, George Carlin’s observations of the “freak show” of humanity, as he often called it, will be sorely missed.

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Summer tunes

During the summer of 2007 there were a few albums that got more than their fair share of playing time. These albums ended up being theme music for last summer, and I have no doubt that listening to them going forward will evoke strong memories of the summer of 2007. Here they are in no particular order:

Coldplay — X&Y: An uncle, of all people, turned me onto this album. I have mixed feelings about Coldplay. They’ve put out some enjoyable songs like Clocks and maybe Yellow, but all-in-all, most of their previous efforts have left me disappointed. That is, until X&Y. There is a veritable quadruplet of songs on this album that are fantastic. Start at Fix You, then Talk, skip X&Y to get to the radio-hit Speed of Sound only to round it out with A Message.

I have no idea why the crammed the mediocre song X&Y in the midst of this fantastic quadruplet of songs, but they did. Oh well. And don’t get me wrong, there are a couple other songs on the album that are “classic Coldplay” in the sense that they are less-than-stellar music. But the awesomeness of the aforemetioned four songs makes up for it. Unfortunately, I fully expect Coldplay to never repeat this confluence of solid music-making.

The Postal Service — Give Up: This album came out awhile ago (Early 2003 to be specific). And I was first introduced to it by my friend Larry after he did a solo cover of “Such Great Heights” and sent me his recording. That was in 2004. It took me three years to follow-up and listen to the album. Give Up is incredible music from the beats and lyrics of Such Great Heights to the provactive imagery of Clark Gable or We will become silhouettes or Recycled air. Even if you don’t care for Ben Gibbard‘s other band (Death Cab for Cutie), there’s a great chance you’ll still like The Postal Service. My only gripe with Give Up is that its too short. Alas, some damn fine music. I’m keeping my ears open for a repeat album.

Foo Fighters — In Your Honor: I only list In Your Honor while admitting that I caught up on the entire Foo Fighters discography last summer. Perhaps not unlike The Postal Service, it just took me awhile to be “ready” for Foo Fighters. Alas, the two-disc set of In Your Honor is fantastic music, and I particularly enjoyed Dave Grohl’s more-or-less solo, acoustic album (i.e. Miracle or On the mend). It’s akin to Beck‘s departure from his normal motif in Sea Change (Another one worth checking out whether you like Beck’s other stuff or not).

Peter, Bjorn & John — Writer’s Block: I picked up this album after hearing Young Folks on some internet radio station. Writer’s Block is just a fun, indie rock album. It’s not genius, but if you’re looking for something slightly different than the mainstream and want an enjoyable album, its worth checking out.

Muse — Black Holes and Revelations: Muse is a bit different, but I found this album to be great workout/biking music. It’s loud, rocking, and some of the lyrics are thought-provoking, if not typically and predictably anti-Bush (yawn). Nonetheless, the album’s namesake song Starlight, which includes the lyric “black holes and revelations”, is fun, weird and enjoyable. Supermassive Black Hole is another different, funkily enjoyable tune. This album is completely associated with biking around Ansley and Piedmont Park.

A request

Now that summer 2008 is fully-on, I’m looking for some new music — good tunes that ultimately end up as my 2008 theme music, forever associated with whatever this summer brings. So if you have any albums you think I might enjoy, please comment below.

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Insulin Control: The Common Denominator of the Low-Carb / Fasting / Caloric Restriction Diets.

Over the past four months, I’ve turned into a staunch advocate of Paleo / low-carb / intermittent fasting (See IF/low-carb, caloric restriction, ketosis, hormesis). I proselytize because this diet lifestyle has had a significant impact on my physical health and my understanding of nutrition. Unfortunately, it wasn’t long before my advocacy spurred the comment that there is “No zealot like the converted.” Oof!

The retort stuck with me. I am a passionate about spreading good ideas. And this idea concerning the health of my friends and family was not only a good idea in theory, but also one in practice. The last thing I wanted was for my zeal to turn individuals away. I needed a better in than “low-carb” or “fasting”.

Unfortunately, there are a lot of pre-conceived notions and pent-up negative biases towards “low-carb” in specific and diets in general. Most people have experienced nothing but disappointment from dieting and/or strict exercise regiments. When the low-carb meme went mainstream a few years ago, non-believers and skeptics rightfully vocalized their doubt. My own curiosity brought me to read a good portion of Atkins New Diet Revolution; however, I was unconvinced. Atkins’ rhetoric was all pathos and little ethos: I needed the science. Not surprisingly, I never even tried the diet, more or less writing it off as just another fad.

Fast-forward to today. There is an ever-growing number of branded low-carbohydrate diets, and additionally, there are a growing number of diets that incorporate caloric restriction or fasting (Popular examples of low-carb and/or fasting include Paleo / DeVany, Protein Power, Atkins, South Beach, Warrior Diet, The Zone, Eat Stop Eat, Fast-5, UpDayDownDay, Bantingism, etc.). Such a plethora of similar yet nuanced regiments is confusing. Who wants to wade through them all to explain their own method? Who wants to lay caveat upon caveat on a diet to tailor fit it to your own experience just to explain it to an inquisitor? My eyes glaze over just thinking about it!

There is a better way. All of these diets have a clear, underlying purpose: to control insulin. Why not just call it Insulin control?

By starting with this core tenet, I can transcend the diet denominational mess.

Insulin control gets to the heart of the matter, which is that excess or chronic insulin in the blood leads to fat storage, loss of insulin sensitivity / increased insulin resistance, downregulation of fat mobilizing hormones (adrenaline, noradrenaline, glucagon and human growth hormone), and can ultimately lead to symptoms of metabolic syndrome, including hypertension, obesity, cardiovascular disease, diabetes and cancer. How do you control insulin? Insulin control can be accomplished via reduction in carbohydrate intake or via controlling feeding times (via fasting) so that insulin levels sufficiently drop, which allows fat mobilization to resume.

Calling what we do “insulin control” focuses on the problem and implies the solution. It also grounds the diet/lifestyle to its fundamental science while avoiding the pitfalls of bias-loaded words. Starting an argument from “insulin control” gets me to low-carb, to fasting, to evolution, to metabolic syndrome, to higher-fat consumption, to more natural/less process foods. Why bother with the varying brands when it’s all about insulin control!

Further reading:

  • Go here to get started on some fantastic quotes on insulin, sugar, glucose, etc. If you’re not already practicing a low-carbohydrate lifestyle, read up.
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Improve your Health via Hormesis – Stress Out.

As alluded to previously, injecting small doses of stress into an otherwise harmonious existence can improve your health. This phenomenon is called hormesis. Here’s a googled definition of hormesis:

A dose response phenomenon whereby a substance that in a high dose inhibits (or is toxic to) a biological process, in a much smaller dose will stimulate (or protect) that same process.

Toxic substances stress us. Stephan explained it nicely over at Whole Health Source:

Hormesis … increases resistance to other, more intense or chronic stressors. It can increase resistance to a variety of stresses, not only the one to which you are exposed.

Hormesis is a powerful, non-obvious-yet-evolutionarily-intuitive idea — I can improve my health by intentionally introducing some stress into my otherwise pampered, stress-free life. And here are a few applications:

  • High-intensity exercise. I lump in here anything that briefly elevates my heart-rate and requires my body to do a significant amount of work. Weight-lifting, sprinting and kettlebell drills readily come to mind.
  • Fasting / Intermittent Fasting. Going without food is quite possibly the easiest path to the benefits of hormesis. Shameless self-promotion: on fasting (application and benefits) and more recently on caloric restriction / resveratrol and the potential for slowing aging.
  • Drinking alcohol. We’ve heard this before — drinking one to two alcoholic beverages a day may benefit cardiovascular health. It seems that the benefit of drinking alcohol is from its hormetic effect.
  • Smoking tobacco. First, I gleaned this application from Arthur De Vany. Dr. DeVany applies it via cigars. I see no reason it could not also be applied via a pipe or some type of snuff or chew. I personally enjoy the occasional cigar or alternatively, will smoke a pipe. One thing to note: inhaling might eliminate the hormetic benefit of tobacco use by taking it from a mild dose to a heavy dose. I simply don’t know.
  • Cold showers. I snagged this one from Richard Nikoley. I then reread the idea from Art and then Stephan, who says it helps fire up “non-shivering thermogenesis”.
  • Radiation. I mention this only for completeness, but small exposure to radiation is a tactic to increase resistance to larger doses of radiation later (Surprise, its controversial). I don’t know of any way for normal folks to apply radiation hormesis.

The above are fairly non-controversial ways to practice “stressing out”, and thereby benefit from hormesis (Excepting radiation hormesis). However, I wonder if there are other things one could do. Here are some alternative hormetic possibilities:

  • Get less sleep. Maybe periodically cut back on your sleep by 30%. I’ve occasionally experienced increased alertness on less sleep. However, the positive effect wears off in time. Prolonged lack of sleep also weakens your immune system, which doesn’t sound too beneficial.
  • Binge on fruit. Assuming you are a low-carber, eating a lot of fruit at one time should result in a sizeable insulin response. If you aren’t on a low-carbohydrate diet, binging on fruit won’t do much to acutely stress your body.
  • Get some sun. Beneficial for Vitamin D purposes, seems like this would also make sense for potential hormetic effects.
  • Expose your kids to allergens. Didn’t know for sure where to put this one and I don’t have kids. However, I’ve read that exposing your kids to cats may reduce the risk of allergies and asthma. Is the benefit here hormesis? Also, is there a risk in overprotecting your kids from germs?

If you have any other ideas for unconventional applications of hormesis, I would love to hear them.

Finally, let’s remember that high doses of toxic substances can impair your health or even kill you. High doses of stress are likewise unhealthy. Therefore, may I present one last list of bad ways to stress out:

  • Over-training (And also, potentially, endurance exercise). Not allowing your body to recover from exercise is a recipe for disaster. Endurance activities like running marathons (or jogging long-distances) might also be harmful (Art De Vany thinks so). I speculate that endurance activities may be safe so long as they are using fat oxidation for energy (See endurance athlete Mark Twight’s write-up on fat). This would necessarily require a lower intensity for most all of us who don’t train to exercise for hours on end — an effort probably no more intense than walking or leisurely riding a bike.
  • Stressing about work, money, family, relationships, career, or the meaning of life. We’ve all done this. However, can you imagine our evolutionary ancestors experiencing existential angst? I can’t. Food availability, yes. Finding shelter, sure. Avoiding predators, certainly. I’m no expert on meditation or any other specific methods for stress reduction. When I get stressed out about life for too long, I just try and step back and see the big picture and/or let go. It helps.
  • Cut back on the caffeine. This is a tough one for me. I drink a good bit of coffee on a daily basis. Caffeine might have hormetic benefits — but I doubt they occur if you’re a chronic user like me.

Anything I missed? If so, please let me know.

Parting thoughts: introduce some “stress” to your life and improve your health. A cold shower followed-up by a 24-hour fast is an easy way to get started. Finish off the fast with some hill sprints. Practice hormesis. If you can consciously control the stressors in your life, you just might live longer.

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Mark Sisson: a Contrarian View on Water

Originally published June 10, 2008. Updated March, 13, 2024.


A contrarian by nature, Mark Sisson’s recent counter-conventional post on water (archived) well worth the read. Bucking the mainstream view that we should drink at least eight glasses (64 oz. total) of water per day, Mark exhaustively details the counterpoint, advocating what seems downright obvious: obey your thirst!

Some takeaways from Mark’s post:

  • We get a lot of water from our food. Mark argues that paleolithic man likely recieved most of his water from food sources. Example: eating fruit will help satisfy your body’s water requirements.
  • Diuretics like coffee, tea and alcohol necessarily contain water, and the diuretic effect only occurs at high, unhealthy doses.
  • Drinking a lot of water before or during a meal can thwart digestion by raising pH levels in your stomach. Raised pH levels can result in indigestion or worse: lowered acidity could reduce the stomach’s ability to destroy susceptible pathogens and other creepy crawlers!
  • The commonly-held mantra that thirst lags dehydration (i.e. “if you’re thirsty, you’re already dehydrated”) is erroneous. Therefore, as one sugary drink prescribes, “Obey your thirst!” with H2O.

Mark packs a lot more into his post.

I have a thought on water some 15 years after Mark penned his missive — perhaps people are so hellbent on water because “drink more water” is a useful bit of diet theater.

Diet theater is like any other act. It’s a performance. People want to believe they are taking care of themselves — the “job to be done” of drinking 8 cups of water is to feel like you’re doing something productive. And hey, even if it’s just a placebo effect kind of productive, maybe that’s enough.

On a related, technical note, in Good Calories, Bad Calories Gary Taubes explains how carbohydrates induce water retention (Fats do not). Assuming I recall correctly, a fat gram has two times the amount of energy as a carbohydrate gram (9 kcal compared to 4). Furthermore, storing a carb gram requires two grams of water. Therefore, energy equivalence between fat and carbohydrates from a volume standpoint is reached at 1:6 fat to carb/water ratio as follows:

1 gm fat = 9 kcal @ 1 gram volume
2 gm carbohydrate + 4 gm water = 8kcal @ 6 grams volume

Thus we see the efficiency of fat as an energy storage vehicle — a whopping 6x as much energy can be stored in the body as fat relative to the volume it would take to store the same amount of energy with carbohydrates!

Between Mark’s comments and Taubes fat-storage efficiency explanation (Would love an online reference here if anyone can find one), I have to wonder: does a low-carb diet go hand-in-hand with lowered water requirements? At first blush, it seems like the answer would be a resounding yes, but I don’t know. Readers?

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Sunday morning

I wake up, but it is still early, so I roll over, readjust and keep my eyes shut. When I finally give in and rise, my cat decides to join me, and does his morning stretch — arched back, curled tail, yawn — you know the drill. I copy him as best I can.

It is quiet.

Coffee. While I wait for it to brew, I gulp down some cold water and feel it invade my throat and stomach. I gulp again but the effect is gone.

Still brewing.

I look out the kitchen window and note the sun’s light is not yet harsh. I imagine it is even bearable outside, maybe even pleasant. It won’t last. The newsman said today will be a scorcher, triple-digits — brutal.

Black coffee.

The warm mug in my hand, I find an inner calm in the new day’s stillness. Another week’s demands lay ahead, but they will wait. Today, I rest.

It’s Sunday morning.

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Caloric Restriction, Red Wine, and Aging

First, a summary:

  • The physiological stress resulting from caloric restriction may extend your life. It could accomplish this by switching resources from reproduction to self-preservation. Alternatively (or additionally), it might accomplish this by helping downregulate insulin, thereby reducing the diseases associated with metabolic syndrome.
  • Resveratrol (Via red wine, for now) might also slow aging via some SIRT-1 mechanism or by somehow signaling to the body that stressful times lay ahead.
  • The stress from exercise3 might slow aging by activating physiological mechanisms of tissue self-preservation, as well.
  • And finally, I can chalk another one up for intermittent fasting, which personal experience says is the easiest way to practice caloric restriction.

The Details

My brother sent me a NYTimes article that talks about resveratrol, a molecule found in red wine, and its possible link to slowing aging. Resveratrol may thwart aging by spurring the production of sirtuins a.k.a. SIRT1 in humans. Per the Times:

[T]he door has now been opened to drugs that exploit an ancient biological survival mechanism, that of switching the body’s resources from fertility to tissue maintenance. The improved tissue maintenance seems to extend life by cutting down on the degenerative diseases of aging.

The reflex can be prompted by a faminelike diet, known as caloric restriction, which extends the life of laboratory rodents by up to 30 percent but is far too hard for most people to keep to and in any case has not been proven to work in humans [See Footnote 1 for discussion on this last sentence].

Whereas the Times article focuses on resveratrol, summarily dismissing caloric restriction, a 2006 article from The Economist does the opposite, going into more detail on the impact of caloric restriction on human aging and a recent study on the matter:

[E]vidence has been accumulating since the 1930s that calorie restriction … extends lifespan and delays the onset of age-related diseases in rats, dogs, fish and monkeys. …

Amid the hype, it is easy to forget that no one has until now shown that calorie restriction works in humans. That omission, however, changed this month, with the publication of the initial results of the first systematic investigation into the matter. This study, known as CALERIE2 (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy), was sponsored by America’s National Institutes of Health. …

CALERIE suggests the [advantages of caloric restriction] are real. For example, those on restricted diets had lower insulin resistance … and lower levels of low-density lipoprotein [LDL] cholesterol. They showed drops in body temperature and blood-insulin levels?both phenomena that have been seen in long-lived, calorie-restricted animals. They also suffered less oxidative damage to their DNA.

The Economist article goes on to talk about resveratrol and even exercise:

Resveratrol is produced when a vine is under stress?for example, due to dehydration or over-exposure to sunshine. According to Dr Sinclair’s theory, which he calls xenohormesis, animals rely on such botanical stress signals to give them extra information about their own environments, in the same way that the alarm calls of one species warn others of danger. If bad things are happening to plants, he surmises, that is a reason for pre-emptive animal action. Animal bodies thus react to molecules such as resveratrol by activating their own defence mechanisms. These, in turn, protect their cells from stress-related damage.

Xenohormesis is a variation of a more general theory, hormesis … A good example of hormesis is exercise. In theory, this should damage cells because it increases oxygen uptake, and oxidative stress is bad for things like DNA. Of course, exercise is not actually bad for cells?and the reason is that the body activates defence mechanisms which overcompensate for the stress the exercise creates, producing beneficial effects. So, while chronic stress is always bad for you[3], a short period of mild stress followed by a period of recovery can be good.

More on hormesis here.

So what’s the common denominator between exercise, resveratrol, and caloric restriction? Stress. The introduction of acute stress may switch the body’s resources from reproduction to self-preservation4. From an evolutionary perspective, this makes sense. If a band of human beings were facing environmental hardship, such as a famine, their bodies would need to self-preserve until times more suitable for the ultimate biological imperative, reproduction.

Beyond acute stress causing self-preservation and thereby slowing aging, there may be another angle here: insulin. Caloric restriction will reduce insulin loads on the body as entering a fasted state will require the body to switch from glucose-burning (Insulin upregulated) to fat-burning (Insulin downregulated). As I’ve blogged before, chronically high insulin (via diets high in carbohydrates) in the blood is positively correlated to metabolic syndrome or Syndrome X. The connection to slowed aging and lower insulin levels could just be the other side of the same coin, but if nothing else, it’s more support for incorporating some amount of caloric restriction in your life.

Footnotes:

1 I’ve got a question out to the author, Nicholas Wade, as to his last claim regarding caloric restriction and its impact (or lack thereof) on humans. I’m fairly certain that Wade means that the life-extending impact of caloric restriction has yet to be proven for humans, even though the CALERIE study mentioned above would contradict such a claim.

I take serious issue with Wade’s ambiguity here. Most of his article is about resveratrol and sirtuins and their potential link to slowing aging in humans. He goes into detail about a pharmaceutical company that is working on producing a drug that might induce the same effects. That’s fine, but why slam the door on an alternative (caloric restriction) that might slow aging for free? Is it because it’s “far too hard for most people”? How did he determine that?

Update 2008-06-13: Received a response to my email to Nicholas Wade. From part of my email:

Or do you mean that sufficient testing on caloric restriction’s impact on human aging has not occurred, thereby the theory remains unproven?

He indicated that the above interpretation was the one he intended. I will let him know about the CALERIE study.

2 Here is the official CALERIE website.

3 Perhaps therein lies some support for the claim that endurance training is unhealthy as it puts a chronic load of stress on the body.

4 Not surprisingly, Art De Vany mentions as much in passing here:

I practice intermittent caloric deprivation. This is a known enhancer of the immune system. This is pure evolutionary reasoning. During deprivation, the system reallocates resources from reproduction to repair and maintenance. The immune system is part of that adaptation.

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Metabolic Pathways while fasted and Ketosis

Was just commenting on Patri Friedman’s livejournal (here) regarding how the metabolic channels used while fasting were the same as those used while on a low-carb diet. Taubes notes fact in passing in Good Calories, Bad Calories but since that’s a hard reference to check on the ‘net, here’s another bit of support from Dr. Mike Eades of Protein Power:

If you read any medical school biochemistry textbook, you’ll find a section devoted to what happens metabolically during starvation. If you read these sections with a knowing eye, you’ll realize that everything discussed as happening during starvation happens during carbohydrate restriction as well. There have been a few papers published recently showing the same thing: the metabolism of carb restriction = the metabolism of starvation. I would maintain, however, based on my study of the Paleolithic diet that starvation and carb restriction are simply the polar ends of a continuum, and that carb restriction was the norm for most of our existence as upright walking beings on this planet, making the metabolism of what biochemistry textbook authors call starvation the ‘normal’ metabolism.

As noted before, this makes intuitive sense. While in a fasted state, the body gets its energy fix by robbing the protein for gluconeogenesis from lean tissue and the fat for energy from adipose tissue. While doing low-carb, the body does the same thing — the only difference is that it gets the fat and protein from dietary sources.

The rest of the Eades article discusses ketones/ketosis, which I’m still working on fully understanding (the basics, anyway). Apparently there are other benefits to occasionally being in a ketogenic state that may include “de-junking” our cells. Neat!

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The Stochasticity of Life

A few months ago, various circumstances led me to a brief bout with depression. It is a strange moment when you reflect that, “I am depressed”. As I’m prone to do when I don’t know much about a subject, I googled depression. As part of my searching, I ended up reading some insightful comments on depression by Art De Vany, who almost three years ago today, was watching his wife succumb to a terminal disease. Regarding depression, Art wrote (emphasis mine):

Are you depressed they ask? And I say no, you only get depressed when you compare the present state with one that is better or perfect in some way. If you accept the reality of the present state, then you can’t make these irrelevant comparisons of what is against the ideal.

You are so strong they say. And I say, no. I am just grounded in the reality of the now and trying to find the best things to do to influence the ensemble of paths on which our lives will evolve from here. If I become depressed or confused, I give up our moment of power. …

The lifepath ensemble formulation is a liberating idea because it makes you understand that you cannot achieve a unique outcome and that the transitions from this state to the next are stochastic. All we can do is to do those things that make favorable transitions more likely.

Not that depression is that bad a thing always. If it is motivating to realize you have fallen short of some attainable goal, it may lead you to improve your preparation for the next life transition. But, if you think you can achieve the change or goal with certainty, then you may become depressed in an unhealthful way. This can fall into a non-linear dynamic that is reinforcing, leading to deeper depression and, eventually, non-competent decisions.

After reading these comments a few months back, I sensed their truth while rejecting their application. Depression is sinister in that it is addictive — I wanted to wallow in my depression rather than work to escape it. It is so easy to be the victim.

Though I won’t elaborate on this further here, it’s likely that what helped me overcome my depression were the positive steps I took1 to improve my health. Not surprisingly, these steps were small to start but have cascaded, compounding their goodness in a non-linear fashion.

Underlying the depression application of De Vany’s comments is a central, important idea: the stochasticity2 of life. De Vany also calls it the “lifepath ensemble formulation”3. These descriptors evoke imagery of a symphony of circumstances, many of which are unpredictable, that drive life forward. So much of life occurs as the sum of a randomness. Even when not random, the number of causal factors in life are often so great as to destroy predictability.

Rather than despair over life’s innate uncertainty and randomness, I accept it. Doing so assuages my anxiety about potentially negative outcomes and empowers me to take the necessarily small steps that will further progress towards a goal. This is even more important when the lifepath ensemble seems nothing more than cacophony. Indeed, the stochasticity of life adds depth and beauty. Would you really have it any other way?

Though I can’t be sure, I bet that is what De Vany means by the “lifepath ensemble” — it is the string of individual actions that come together to set a course for my life. The course will be anything but certain, so accept the uncertainty, and work within it.

Extracurricular reading

  • Anyone else reminded of Knocked Up? There’s a line in that movie spoken by the father (played by Harold Ramis) to Ben (Seth Rogen) that goes something like “Life doesn’t care about your plans!”
  • I might have to blog on this in more detail later, but Scott Adams, the creator of Dilbert, practices “affirmations”. Affirmations is a method whereby you write out a specific goal 15 times a day for as long as it takes (at least six months) for the goal to manifest itself in your life. Mystical enough for you? Adams says he practiced affirmations regarding becoming a syndicated cartoonist. His affirmation was “I Scott Adams will become a syndicated cartoonist.” Correlation is not causation; however, I can imagine a causal pathway whereby writing down a specific goal encourages you to focus on means to accomplish the goal, consciously or otherwise. Alternatively, focusing on the goal raises your awareness and helps you tune out much of the stochastic noise of life and focus on taking those small steps. Here is a re-post4 of Adams’ post. Note: I have not tried affirmations.
  • My sister clued me in to Earl Nightingale’s “Strangest Secret in the World.” You can listen to it but the secret is that “we become what we think about”. Again, the method by which thought becomes action is unclear; however, it seems obvious that we will actualize our desires and our desires spring from our thought. So think!

Footnotes

1 Art played an indirect, but prominent role in that process, as well, so I probably owe Dr. De Vany a “thank you” or two.

2 To save anyone from looking this up — as I had to, “stochasticity” means:

the quality of lacking any predictable order or plan

3 Such a provocative descriptor and yet he has not since blogged on the “lifepath ensemble” again — 1 2

4 Quite bizarrely, the original blog post by Adams on his Dilbert Blog (http://dilbertblog.typepad.com/) has disappeared. You can do the googling yourself if you don’t believe me. Strikes me as odd. Note: in the original post, Adams alluded to a book on luck by Richard Wiseman. That post is still out there for the reading.