http://www.arthurdevany.com/?p=1054
Art had this to say back when the post was still live:
Aside from NPY, belly fat secretes tumor necrosis factor and a host of other hormones and messengers that make other tissues resistant to the action of insulin. This, in effect, redirects nutrients to them away from other tissues such as muscle, organ and brain. They also elevate serum triglycerides that can directly poison insulin beta cells and receptors.